Human Glutamate Cysteine Ligase Catalytic Subunit, GCLC ELISA Kit

SKU: E5338Hu

Size:96 Tests-1 Kit

Background:Glutamate—cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:GCLC

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Glutamate--cysteine ligase catalytic subunit

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P48506

MASS(Da):72,766

GeneID:2729

Synonyms:Gamma-ECS;Gamma-glutamylcysteine synthetase;GCL;GCLC;GCS;GCS heavy chain;GLCL;GLCLC;Glutamate--cysteine ligase catalytic subunit;

Gene names:GCLC

Standard solution:24ng/ml