Human Gasdermin-C,GSDMC ELISA KIT

SKU: E7249Hu

Size:96 Tests-1 Kit

Background:[Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. {ECO:0000250|UniProtKB:Q96QA5}.; [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:27281216). Released upon cleavage and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity). The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (Probable). {ECO:0000250|UniProtKB:Q96QA5, ECO:0000269|PubMed:27281216, ECO:0000305}.

Research_area:

Applications:ELISA

Target_protein:GSDMC

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.04ng/ml

Detection range:3.75-240ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BYG8

MASS(Da):57692

GeneID:56169

Synonyms:GSDMC MLZE

Gene names:GSDMC

Standard solution:480ng/ml