Human Gasdermin-A,GSDMA ELISA KIT

SKU: E7247Hu

Size:96 Tests-1 Kit

Background:[Gasdermin-A]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death. {ECO:0000269|PubMed:27281216}.; [Gasdermin-A, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:17471240, PubMed:27281216). Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:27281216). Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:27281216). The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (PubMed:27281216). {ECO:0000269|PubMed:17471240, ECO:0000269|PubMed:27281216}.

Research_area:

Applications:ELISA

Target_protein:GSDMA

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.59ng/ml

Detection range:3.13-200ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96QA5

MASS(Da):49365

GeneID:284110

Synonyms:GSDMA GSDM GSDM1 FKSG9

Gene names:GSDMA

Standard solution:400ng/ml