Human Frataxin,FXN ELISA KIT

SKU: E4188hu

Size:96 Tests-1 Kit

Background:Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. {ECO:0000269|PubMed:12785837, ECO:0000269|PubMed:15247478, ECO:0000269|PubMed:15641778, ECO:0000269|PubMed:16239244, ECO:0000269|PubMed:16608849, ECO:0000269|PubMed:20053667}.

Research_area:

Applications:ELISA

Target_protein:FXN

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.65ng/ml

Detection range:5-320ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Frataxin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q16595

MASS(Da):23135

GeneID:2395

Synonyms:FXN FRDA X25

Gene names:FXN

Standard solution:640ng/ml