Human FMS-like tyrosine kinase 3,Flt3 ELISA KIT

SKU: E0910Hu

Size:96 Tests-1 Kit

Background:Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}.

Research_area:

Applications:ELISA

Target_protein:FLT3

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.52pg/ml

Detection range:10-2000pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:FMS-like tyrosine kinase 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P36888

MASS(Da):112903

GeneID:2322

Synonyms:FLT3 CD135 FLK2 STK1

Gene names:FLT3

Standard solution:2400pg/ml