Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, EIF2AK3 ELISA Kit

SKU: E7149Hu

Size:96 Tests-1 Kit

Background:Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Research_area:Others

Applications:ELISA

Target_protein:EIF2AK3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3,Eif2Ak3,

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NZJ5

MASS(Da):125,216

GeneID:9451

Synonyms:EIF2AK3;Eukaryotic translation initiation factor 2-alpha kinase 3;HsPEK;Pancreatic eIF2-alpha kinase;PRKR-like endoplasmic reticulum kinase

Gene names:EIF2AK3

Standard solution:16ng/ml