Human Erlin-2, ERLIN2 ELISA Kit

SKU: E5260Hu

Size:96 Tests-1 Kit

Background:Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed: 19240031, PubMed: 17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed: 21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed: 24217618).

Research_area:Neuroscience

Applications:ELISA

Target_protein:ERLIN2

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.15ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Erlin-2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O94905

MASS(Da):37,840

GeneID:11160

Synonyms:Endoplasmic reticulum lipid raft-associated protein 2;ERLIN 2;ERLIN2;Erlin-2;SPFH domain-containing protein 2;Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2

Gene names:ERLIN2

Standard solution:2560ng/L