Human Ephrin Type-A Receptor 1, EPHA1 ELISA Kit

SKU: E5244Hu

Size:96 Tests-1 Kit

Background:Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Research_area:Others

Applications:ELISA

Target_protein:EPHA1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.031ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Ephrin Type-A Receptor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P21709

MASS(Da):108,127

GeneID:2041

Synonyms:EPH tyrosine kinase;EPH tyrosine kinase 1;EPHA 1;EPHA1;Ephrin type-A receptor 1;Erythropoietin-producing hepatoma receptor;hEpha1;Tyrosine-protein kinase receptor EPH

Gene names:EPHA1

Standard solution:25.6ng/mL