Human Endoglin, ENG ELISA Kit

SKU: E3407Hu

Size:96 Tests-1 Kit

Background:Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed: 21737454, PubMed: 23300529). Required for normal structure and integrity of adult vasculature (PubMed: 7894484). Regulates the migration of vascular endothelial cells (PubMed: 17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed: 1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed: 8370410, PubMed: 21737454, PubMed: 22347366, PubMed: 23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed: 21737454, PubMed: 22347366, PubMed: 23300529).

Research_area:Cancer

Applications:ELISA

Target_protein:ENG

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.16ng/ml

Detection range:0.3-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Endoglin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17813

MASS(Da):70,578

GeneID:2022

Synonyms:CD antigen CD105;Endoglin;ENG

Gene names:ENG

Standard solution:80ng/ml