Human Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A,DYRK1A ELISA KIT

SKU: E7476Hu

Size:96 Tests-1 Kit

Background:Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.

Research_area:

Applications:ELISA

Target_protein:DYRK1A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.018ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13627

MASS(Da):85584

GeneID:1859

Synonyms:DYRK1A DYRK MNB MNBH

Gene names:DYRK1A

Standard solution:24ng/ml