Human DNA Damage-inducible Transcript 4 Protein, DDIT4 ELISA Kit

SKU: E5190Hu

Size:96 Tests-1 Kit

Background:Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:DDIT4

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.018ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:DNA damage-inducible transcript 4 protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NX09

MASS(Da):25,371

GeneID:54541

Synonyms:DDIT4;Dig2;DNA damage-inducible transcript 4 protein;HIF-1 responsive protein RTP801;Protein regulated in development and DNA damage response 1;REDD1;REDD-1

Gene names:DDIT4

Standard solution:24ng/ml