Human Cytochrome P450c21;21-hydroxylase,CYP21A2 ELISA KIT

SKU: E0794Hu

Size:96 Tests-1 Kit

Background:A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:10602386, PubMed:16984992, PubMed:22014889, PubMed:27721825). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791). {ECO:0000269|PubMed:10602386, ECO:0000269|PubMed:16984992, ECO:0000269|PubMed:22014889, ECO:0000269|PubMed:25855791, ECO:0000269|PubMed:27721825}.

Research_area:

Applications:ELISA

Target_protein:CYP21A2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.21ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Cytochrome P450c21;21-hydroxylase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08686

MASS(Da):55887

GeneID:1589

Synonyms:CYP21A2 CYP21 CYP21B

Gene names:CYP21A2

Standard solution:48ng/ml