Human Cox7A1 ELISA Kit

SKU: E5155Hu

Size:96 Tests-1 Kit

Background:Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:COX7A1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.49ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cytochrome c oxidase subunit 7A1, mitochondrial

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P24310

MASS(Da):9,118

GeneID:1346

Synonyms:COX7A;COX7A1;COX7AH;COX7AM;Cytochrome c oxidase subunit 7A1, mitochondrial;Cytochrome c oxidase subunit VIIa-H;Cytochrome c oxidase subunit VIIa-heart;Cytochrome c oxidase subunit VIIa-M;Cytochrome c oxidase subunit VIIa-muscle;

Gene names:COX7A1

Standard solution:3200ng/L