Human complement C5a ELISA Kit PicoKine®

SKU: EK0966

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: C5

Specificity: Natural and recombinant human complement C5a

Background: C5a is a protein fragment released from complement component C5. This gene is mapped to 9q33.2. The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to susceptibility to liver fibrosis and to rheumatoid arthritis.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: T678-R751

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Reference:

Uniprot ID: P01031

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 727

Protein Name: Complement C5

Gene Full Name: complement C5

Synonyms: C5; Complement C5; complement component 5; CPAMD4