Human Clip-Associating Protein 2, CLASP2 ELISA Kit

SKU: E5053Hu

Size:96 Tests-1 Kit

Background:Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed: 26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed: 16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed: 16866869, PubMed: 16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Research_area:Cell Biology

Applications:ELISA

Target_protein:CLASP2

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.12ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Clip-Associating Protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75122

MASS(Da):141,064

GeneID:23122

Synonyms:CLASP 2;CLASP2;CLIP-associating protein 2;Cytoplasmic linker-associated protein 2;hOrbit2;Protein Orbit homolog 2

Gene names:CLASP2

Standard solution:3200ng/L