Human Chromobox Protein Homolog 2, CBX2 ELISA Kit

SKU: E2894Hu

Size:96 Tests-1 Kit

Background:Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed: 21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed: 21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed: 19361780).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:CBX2

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.71ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Chromobox Protein Homolog 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q14781

MASS(Da):56,081

GeneID:84733

Synonyms:CBX 2;CBX2;Chromobox protein homolog 2

Gene names:CBX2

Standard solution:1600ng/L