Human Chitotriosidase/CHIT1 ELISA Kit PicoKine®

SKU: EK2032

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CHIT1

Specificity: Natural and recombinant human CHIT1

Background: Chitotriosidase encoded by the CHIT1 gene is a member of the chitinase family that is selectively expressed in activated tissue macrophages. This gene is mapped to 1q32.1. Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A22-N466

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Reference:

Uniprot ID: Q13231

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1118

Protein Name: Chitotriosidase-1

Gene Full Name: chitinase 1

Synonyms: CHI3; CHIT; CHIT1; Chitinase 1; chitinase 1 (chitotriosidase); Chitotriosidase 1