Human CCL22/MDC PicoKine® Quick ELISA Kit

SKU: FEK0446

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CCL22

Specificity: Natural and recombinant human CCL22

Background: Macrophage-derived chemokine (MDC), also called Chemokine, cc motif, ligand 22 (CCL22) or Small inducible cytokine subfamily A, member 22 (SCY22). MDC is a recently identified member of the CC chemokine family. It is not closely related to other chemokines, sharing most similarity with thymus- and activation-regulated chemokine (TARC), which contains 37% identical amino acids. In addition, MDC gene is mapped to chromosome 16q13, the same position reported for the TARC gene. MDC has the four-cysteine motif and other highly conserved residues characteristic of CC chemokines, but it shares<35% identity with any of the known chemokines. Recombinant MDC was expressed in Chinese hamster ovary cells and purified by heparin-Sepharose chromatography. MDC is highly expressed in macrophages and in monocyte-derived dendritic cells, but not in monocytes, natural killer cells, or several cell lines of epithelial, endothelial, or fibroblast origin. High expression was also detected in normal thymus and less expression in lung and spleen. MDC is thus a unique member of the CC chemokine family that may play a fundamental role in the function of dendritic cells, natural killer cells, and monocytes.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: G25-Q93

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Uniprot ID: O00626

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 6367

Protein Name: C-C motif chemokine 22

Gene Full Name: C-C motif chemokine ligand 22

Synonyms: A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22; STCP-1; CCL22