Human Caveolin-1, CAV-1 ELISA Kit

SKU: E1727Hu

Size:96 Tests-1 Kit

Background:May act as a scaffolding protein within caveolar membranes (PubMed: 11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed: 19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed: 17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed: 25893292).

Research_area:Immunology

Applications:ELISA

Target_protein:CAV1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.151ng/ml

Detection range:0.3-90ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Caveolin-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q03135

MASS(Da):20,472

GeneID:857

Synonyms:CAV 1;CAV1;Caveolin-1

Gene names:CAV1

Standard solution:96ng/ml