Human Carbonyl Reductase Nadph 1, CBR1 ELISA Kit

SKU: E6599Hu

Size:96 Tests-1 Kit

Background:NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).

Research_area:Signal Transduction; Cell Biology; Metabolism

Applications:ELISA

Target_protein:CBR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.31ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Carbonyl reductase [NADPH] 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P16152

MASS(Da):30,375

GeneID:873

Synonyms:20-beta-hydroxysteroid dehydrogenase;Carbonyl reductase [NADPH] 1;CBR;CBR1;CRN;hCBR1;NADPH-dependent carbonyl reductase 1;PG-9-KR;Prostaglandin 9-ketoreductase;Prostaglandin-E(2 9-reductase;SDR21C1;Short chain dehydrogenase/reductase family 21C member 1

Gene names:CBR1

Standard solution:4800ng/L