Human Bcl2;adenovirus E1B 19 kDa protein-interacting protein 3,BNIP3 ELISA KIT

SKU: E2458Hu

Size:96 Tests-1 Kit

Background:Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.

Research_area:

Applications:ELISA

Target_protein:BNIP3

Reactivity:Human

Assay type:Sandwich

Sensitivity:23.8ng/L

Detection range:50-3200ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Bcl2;Adenovirus E1B 19kDa Interacting Protein 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q12983

MASS(Da):21541

GeneID:664

Synonyms:BNIP3 NIP3

Gene names:BNIP3

Standard solution:6400ng/L