Human Bcl-2-like Protein 1, BCLX ELISA Kit

SKU: E4035hu

Size:96 Tests-1 Kit

Background:Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion Channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP Synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed: 17418785). Isoform Bcl-X(S) promotes apoptosis.

Research_area:Cell Biology

Applications:ELISA

Target_protein:BCL2L1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.13ng/mL

Detection range:0.3-90ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Bcl-2-Like Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q07817

MASS(Da):26,049

GeneID:598

Synonyms:Apoptosis regulator Bcl-X;BCL2L1;Bcl2-L-1;Bcl-2-like protein 1

Gene names:BCL2L1

Standard solution:96ng/mL