Human B- and T-lymphocyte Attenuator, BTLA ELISA Kit

SKU: E6529Hu

Size:96 Tests-1 Kit

Background:Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).

Research_area:Immunology

Applications:ELISA

Target_protein:BTLA

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.095ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:B- and T-lymphocyte attenuator

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q7Z6A9

MASS(Da):32,834

GeneID:151888

Synonyms:B- and T-lymphocyte attenuator;B- and T-lymphocyte-associated protein;BTLA;BTLA1;CD antigen CD272;CD272

Gene names:BTLA

Standard solution:64ng/ml