Human Autism Susceptibility Gene 2 Protein, AUTS2 ELISA Kit

SKU: E4423Hu

Size:96 Tests-1 Kit

Background:Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed: 25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed: 25519132). As a consequence, the complex mediates transcriptional activation (PubMed: 25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:AUTS2

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.62ng/L

Detection range:10-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Autism Susceptibility Gene 2 Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8WXX7

MASS(Da):138,982

GeneID:26053

Synonyms:Autism susceptibility gene 2 protein;AUTS 2;AUTS2

Gene names:AUTS2

Standard solution:3200ng/L