Human Atp-binding Cassette Sub-family A Member 2, ABCA2 ELISA Kit

SKU: E2421Hu

Size:96 Tests-1 Kit

Background:Probable lipid tranporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed: 15238223, PubMed: 21810484, PubMed: 24201375) (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed: 24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed: 22086926, PubMed: 26510981). May play a role in myelin formation (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:ABCA2

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.57ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Atp-Binding Cassette Sub-Family A Member 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BZC7

MASS(Da):269,833

GeneID:20

Synonyms:ABCA 2;ABCA2;ATP-binding cassette 2;ATP-binding cassette sub-family A member 2;ATP-binding cassette transporter 2

Gene names:ABCA2

Standard solution:2400ng/L