Human Alpha-Synuclein, SNCA ELISA Kit

SKU: E1313Hu

Size:96 Tests-1 Kit

Background:Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed: 28288128, PubMed: 30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed: 30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed: 20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed: 20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed: 26442590).

Research_area:Neuroscience

Applications:ELISA

Target_protein:SNCA

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.15pg/ml

Detection range:10-1000pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Alpha-Synuclein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P37840

MASS(Da):14,460

GeneID:6622

Synonyms:Alpha-synuclein;NACP;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;SNCA

Gene names:SNCA

Standard solution:1280pg/ml