Human Aldo-keto Reductase Family 1, Member B1, AKR1B1 ELISA Kit

SKU: E3400Hu

Size:96 Tests-1 Kit

Background:Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed: 1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed: 12732097, PubMed: 19010934, PubMed: 8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed: 17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed: 21329684).

Research_area:Metabolism

Applications:ELISA

Target_protein:AKR1B1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.02ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Aldo-Keto Reductase Family 1, Member B1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P15121

MASS(Da):35,853

GeneID:231

Synonyms:AKR1B1;Aldehyde reductase;Aldo-keto reductase family 1 member B1;Aldose reductase;AR

Gene names:AKR1B1

Standard solution:40ng/ml