Human AKR1C3 ELISA Kit PicoKine®

SKU: EK1869

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: AKR1C3

Specificity: Natural and recombinant human AKR1C3

Background: Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene. It is mapped to 10p15.1. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: M1-Y323

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Uniprot ID: P42330

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 8644

Protein Name: Aldo-keto reductase family 1 member C3

Gene Full Name: aldo-keto reductase family 1 member C3

Synonyms: 17 beta HSD 5; 3 alpha HSD type 2; 3 alpha HSD type II; brain; AKR1C3; DD 3; DD3; DDX; Dihydrodiol dehydrogenase 3; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; Indanol dehydrogenase; KIAA0119; PGFS; Prostaglandin F synthase