Human Adseverin, SCIN ELISA Kit

SKU: E6742Hu

Size:96 Tests-1 Kit

Background:Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:SCIN

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.18ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Adseverin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y6U3

MASS(Da):80,489

GeneID:85477

Synonyms:Adseverin;SCIN;Scinderin

Gene names:SCIN

Standard solution:4800ng/L