Human Achaete-scute homolog 1,ASCL1 ELISA KIT

SKU: E3598Hu

Size:96 Tests-1 Kit

Background:Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity). {ECO:0000250|UniProtKB:Q02067}.

Research_area:

Applications:ELISA

Target_protein:ASCL1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.25ng/mL

Detection range:0.5-32ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Achaete-scute homolog 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P50553

MASS(Da):25454

GeneID:429

Synonyms:ASCL1 ASH1 BHLHA46 HASH1

Gene names:ASCL1

Standard solution:64ng/mL