Human 2-oxoglutarate dehydrogenase complex component E1,OGDH ELISA KIT

SKU: E7589Hu

Size:96 Tests-1 Kit

Background:2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate (PubMed:24495017). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:24495017). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). {ECO:0000269|PubMed:24495017, ECO:0000269|PubMed:29211711}.

Research_area:

Applications:ELISA

Target_protein:OGDH

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.41ng/ml

Detection range:0.75-48ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q02218

MASS(Da):115935

GeneID:4967

Synonyms:OGDH

Gene names:OGDH

Standard solution:96ng/ml