HDAC6 Antibody - Cat. #: CSB-PA010242ESR1HU

SKU: CSB-PA010242ESR1HU

Size :50ul

Clone Number:

Aliases:CPBHM antibody; FLJ16239 antibody; HD 6 antibody; HD6 antibody; HDAC 6 antibody; HDAC6 antibody; HDAC6_HUMAN antibody; Histone deacetylase 6 (HD6) antibody; Histone deacetylase 6 antibody; JM 21 antibody; JM21 antibody; KIAA0901 antibody; OTTHUMP00000032398 antibody; OTTHUMP00000197663 antibody; PPP1R90 antibody; Protein phosphatase 1 regulatory subunit 90 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UBN7

Immunogen:Recombinant Human Histone deacetylase 6 protein (160-470AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:HDAC6

Research Areas:Epigenetics and Nuclear Signaling; Stem cells