FZD6 Polyclonal Antibody

SKU: E-AB-12926

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:FZD6

Target Synonym:Frizzled 6 seven transmembrane spanning receptor;Frizzled drosophila homolog of 6;Frizzled family receptor 6;Frizzled homolog 6 (Drosophila);Frizzled homolog 6;Frizzled-6;Frizzled6;Fz 6;Fz-6;Fz6;FZD 6;Fzd6;FZD6;Hfz 6;hFz6;NDNC10

Research Areas:Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:O60353

Accession:

Background:This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Concentration:0.2 mg/mL

Immunogen:Synthetic peptide of human FZD6

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:100-1:300

Calculated MW:

ObservedMW: