FZD4 Antibody, HRP conjugated - Cat. #: CSB-PA890755LB01HU

SKU: CSB-PA890755LB01HU

Size :50ug

Clone Number:

Aliases:CD 344 antibody; CD 344 antigen antibody; CD344 antibody; CD344 antigen antibody; EVR1 antibody; FEVR antibody; Frizzled (Drosophila) homolog 4 antibody; Frizzled 4 antibody; Frizzled family receptor 4 antibody; Frizzled homolog 4 (Drosophila) antibody; Frizzled-4 antibody; Fz 4 antibody; Fz-4 antibody; Fz4 antibody; FZD4 antibody; FZD4_HUMAN antibody; FZD4S antibody; FzE4 antibody; GPCR antibody; hFz4 antibody; MGC34390 antibody; WNT receptor frizzled 4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9ULV1

Immunogen:Recombinant Human Frizzled-4 protein (37-222AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FZD4

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction; Stem cells