Frizzled-7 rabbit pAb

SKU: ES2373

Size: 100μL

Source:Rabbit

Applications:WB;Flow Cyt;IF;ELISA

Reactivity:Human;Mouse

Dilution:WB 1:500-2000;Flow Cyt 1:50-200;IF/ICC 1:100-500;ELISA 1:5000-20000

Immunogen:The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):64kD

Human_gene_id:8324

Human_swiss_prot_no:O75084

Subcellular_location:Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. .

Other_name:FZD7; Frizzled-7; Fz-7; hFz7; FzE3

Background:frizzled class receptor 7(FZD7) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008],