FLT1 Monoclonal Antibody

SKU: BT-MCA4760

Size:100μL

Background:Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), also known as FLT1 or VEGFR-1. It is a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Research_area:Cardiovascular

Target_protein:FLT1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:3D10

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:FLT1

Immunogen:Purified recombinant extracellular fragment of human FLT1 fused with hIgGFc tag expressed in HEK293 cells.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):100kDa

UniProt accession:P17948

Synonyms:FLT, VEGFR1

GeneID:2321