FBX32 Rabbit Polyclonal Antibody

SKU: BT-AP02650

Size:100μL

Background:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif| the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box)| which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains| Fbls containing leucine-rich repeats| and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy| whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research_area:Cardiovascular; Cell biology; Stem cells

Target_protein:FBXO32

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:FBX32

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q969P5; Mouse: Q9CPU7; Rat: Q91Z62

Synonyms:FBX32; F-box only protein 32; Atrogin-1; Muscle atrophy F-box protein; MAFbx)

GeneID:Human: 114907; Mouse: 67731; Rat: 171043