FANCD2 antibody , Cat. # FNab03006

SKU: FNab03006

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.The antibody recognize both un-phospho and phospho-Ser(330) of FANCD2.

Immunogen:Fanconi anemia, complementation group D2

Synonyms:DKFZp762A223, FA D2, FA4, FACD, FAD, FAD2, FANCD, FANCD2, FLJ23826, Protein FACD2

Observed MW:150-155kd

Uniprot ID:Q9BXW9

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200

Gene ID:2177

Research Area:Epigenetics, Metabolism