ESR1 Monoclonal Antibody

SKU: BT-MCA4481

Size:100μL

Background:ESR1: estrogen receptor 1. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Research_area:Signal Transduction

Target_protein:ESR1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:10H12B10

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ESR1

Immunogen:Purified recombinant fragment of ESR1 (aa301-595) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:P03372

Synonyms:ER, ESR, Era

GeneID:2099