ERBB3 Antibody - Cat. #: CSB-PA578770

SKU: CSB-PA578770

Size :50ul

Clone Number:

Aliases:c erbB 3 antibody; c erbB3 antibody; Erb b2 receptor tyrosine kinase 3 antibody; ErbB 3 antibody; ERBB3 antibody; ERBB3 protein antibody; erbB3 S antibody; ERBB3_HUMAN antibody; Glial growth factor receptor antibody; HER 3 antibody; HER3 antibody; Human epidermal growth factor receptor 3 antibody; LCCS2 antibody; MDA BF 1 antibody; MGC88033 antibody; p180 ErbB3 antibody; p45 sErbB3 antibody; p85 sErbB3 antibody; proto-oncogene-like protein c ErbB 3 antibody; proto-oncogene-like protein c ErbB3 antibody; Proto-oncogene-like protein c-ErbB-3 antibody; Receptor tyrosine protein kinase erbB 3 antibody; Receptor tyrosine protein kinase erbB3 antibody; Receptor tyrosine-protein kinase erbB-3 antibody; Tyrosine kinase type cell surface receptor HER3 antibody; Tyrosine kinase-type cell surface receptor HER3 antibody; v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody; v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody; v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P21860

Immunogen:Fusion protein of Human ERBB3

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:25-1:100

Background:This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ERBB3

Research Areas:Cancer;Tags & Cell Markers;Signal transduction