EphB4 Monoclonal Antibody

SKU: BT-MCA4356

Size:100μL

Background:EPH receptor B4 (EphB4), with 987-amino acid protein (about 108kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptor tyrosine kinases and their ligands, the ephrins, regulate numerous biological processes in developing and adult tissues and have been implicated in cancer progression and in pathological forms of angiogenesis. EphB4 acts as a negative regulator of blood vessel branching and vascular network formation, switching the vascularization program from sprouting angiogenesis to circumferential vessel growth. EphB4 and its ligand ephrinB2 express in several kinds of tumor cells and correlate with tumorigenesis. EphB4 is thus a potential candidate as a predictor of disease outcome in several kinds of tumor and as target for novel therapy.

Research_area:Cardiovascular

Target_protein:EphB4

applications:IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:5B8F7

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:EphB4

Immunogen:Purified recombinant fragment of EphB4 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:P54760

Synonyms:HTK, MYK1, TYRO11

GeneID:2050