EP300 Monoclonal Antibody

SKU: BT-MCA2135

Size:100μL

Background:EP300: E1A binding protein p300. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:EP300

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:7D8A6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:EP300

Immunogen:Purified recombinant fragment of EP300 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:Q09472

Synonyms:p300, KAT3B

GeneID:2033