eIF4A1 Mouse mAb

SKU: EM1136

Size: 100μL

Source:Mouse

Applications:WB, IHC, IF

Reactivity:Human, Rat, Mouse

Dilution:WB 1:1,000-3,000 IF 1:100-200 IHC 1:100-200

Immunogen:Synthetic Peptide

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):48kDa

Human_gene_id:1973

Human_swiss_prot_no:P60842

Subcellular_location:Cytosol,Extracellular region or secreted

Other_name:DDX2, eIF 4A I, Eukaryotic initiation factor 4A-1, ATP-dependent RNA helicase eIF4A-1,DDX2A

Background:The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. Eukaryotic initiation factor (eIF) complex 2 forms a ternary complex with GTP and the initiator Met-tRNA – this process is regulated by guanine nucleotide exchange and phosphorylation and serves as the main regulatory element of the bottleneck of protein expression.