EFNA1 Antibody - Cat. #: CSB-PA551061

SKU: CSB-PA551061

Size :100ul

Clone Number:

Aliases:B61 antibody; ECKLG antibody; EFL 1 antibody; EFL1 antibody; EFNA 1 antibody; Efna1 antibody; EFNA1_HUMAN antibody; EPH related receptor tyrosine kinase ligand 1 antibody; EPH-related receptor tyrosine kinase ligand 1 antibody; Ephrin-A1 antibody; Ephrin-A1, secreted form antibody; EphrinA1 antibody; EPLG 1 antibody; EPLG1 antibody; Immediate early response protein B61 antibody; LERK 1 antibody; LERK-1 antibody; LERK1 antibody; Ligand of eph related kinase 1 antibody; OTTHUMP00000033242 antibody; OTTHUMP00000033271 antibody; secreted form antibody; TNF alpha-induced protein 4 antibody; TNFAIP 4 antibody; TNFAIP4 antibody; Tumor necrosis factor alpha induced protein 4 antibody; Tumor necrosis factor alpha-induced protein 4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P20827

Immunogen:Synthesized peptide derived from internal of Human EFNA1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500

Background:Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Holzman L.B., Mol. Cell. Biol. 10:5830-5838(1990).
Gregory S.G., Nature 441:315-321(2006).
Zhang Z., Protein Sci. 13:2819-2824(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:EFNA1

Research Areas:Neuroscience;Cardiovascular;Signal transduction