E7 Antibody, Biotin conjugated - Cat. #: CSB-PA361948LD01HMN

SKU: CSB-PA361948LD01HMN

Size :50ug

Clone Number:

Aliases:E7Protein E7 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human) papillomavirus type 18

UniProt ID:P06788

Immunogen:Recombinant Human papillomavirus type 18 Protein E7 protein (1-105AA)

Raised in:Rabbit

Species Reactivity:Human papillomavirus type 18

Tested Applications:ELISA

Background:E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:E7

Research Areas:Others