E-Cadherin Polyclonal Antibody

SKU: AN004540L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:E-Cadherin

Target Synonym:Arc 1;Arc 1;CADH1;Cadherin 1;cadherin 1 type 1 E-cadherin;Cadherin1;CAM 120/80;CD 324;CD324;CD324 antigen;cdh1;CDHE;E-Cad/CTF3;E-cadherin;ECAD;Epithelial cadherin;epithelial calcium dependant adhesion protein;LCAM;Liver cell adhesion molecule;UVO;Uvomorulin;Arc-1;Cadherin 1;cadherin 1 type 1 E-cadherin;Cadherin1;CD 324;CD324 antigen;E-Cad/CTF3;epithelial calcium dependant adhesion protein;Liver cell adhesion molecule;CDH;Arc;CADH;CD antigen CD;Cleaved into: E-Cad/CTF;Cadherin;CAM 120/;Arc-1;CD324;CDHE;ECAD;LCAM;UVO;CDH1;E-Cadherin;CADH1;Cadherin-1;Uvomorulin;E-Cad;CTF2;CAM 120/80;Epithelial cadherin;CD antigen CD324;Cleaved into: E-Cad/CTF1;CTF3; CDH1

Research Areas:Signal Transduction;Cancer;Developmental Biology;Tags & Cell Markers

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P12830

Accession:

Background:Epithelial (E) - Cadherin (ECAD), also known as cell-CAM120/80 in the human, uvomorulin in the mouse, Arc-1 in the dog, and L-CAM in the chicken, is a member of the cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha, beta, and gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. E-Cadherin may also play a role in tumor development, as loss of E-Cadherin has been associated with tumor invasiveness. E-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium‑dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. E‑Cadherin contains five extracellular calcium-binding domains of approximately 110 amino acids each.

Concentration:1 mg/mL

Immunogen:Recombinant Human E-Cadherin protein expressed by E.coli

Buffer:PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:250-1:500

Calculated MW:98 kDa

ObservedMW:120 kDa