DUOX1 rabbit pAb

SKU: ES16881

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Rat

Dilution:WB 1：500-2000

Immunogen:Synthesized peptide derived from human DUOX1 AA range: 1398-1448

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:53905

Human_swiss_prot_no:Q9NRD9

Subcellular_location:Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells.

Other_name:

Background:The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012],