DOCK7 Antibody, FITC conjugated - Cat. #: CSB-PA836266LC01HU

SKU: CSB-PA836266LC01HU

Size :50ug

Clone Number:

Aliases:DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96N67

Immunogen:Recombinant Human Dedicator of cytokinesis protein 7 protein (1440-1671AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 \\\'Ser-15\\\' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DOCK7

Research Areas:Neuroscience; Developmental biology; Signal transduction