DISC1 Antibody - Cat. #: CSB-PA889093LA01HU

SKU: CSB-PA889093LA01HU

Size :50ug

Clone Number:

Aliases:C1orf136 antibody; DISC1 antibody; DISC1_HUMAN antibody; Disrupted in schizophrenia 1 antibody; Disrupted in schizophrenia 1 protein antibody; KIAA0457 antibody; RP4-730B13.1 antibody; SCZD9 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NRI5

Immunogen:Recombinant Human Disrupted in schizophrenia 1 protein (99-325AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:200

Background:Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DISC1

Research Areas:Neuroscience