DIO2 Antibody - Cat. #: CSB-PA440740

SKU: CSB-PA440740

Size :50ul

Clone Number:

Aliases:5DII antibody; D2 antibody; Deiodinase, iodothyronine, type II antibody; DIO2 antibody; DIOII antibody; EC 1.97.1.10 antibody; IOD2_HUMAN antibody; ITDI2 antibody; SelY antibody; Thyroxine deiodinase, type II antibody; TXDI2 antibody; Type 2 DI antibody; Type 2 iodothyronine deiodinase antibody; Type II 5' deiodinase antibody; Type II iodothyronine deiodinase antibody; Type-II 5''-deiodinase antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q92813

Immunogen:Synthetic peptide of Human DIO2

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; ELISA:1:1000-1:2000, WB:1:200-1:1000

Background:The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DIO2

Research Areas:Others